Indicators on phenobarbital sodium obat apa You Should Know
Indicators on phenobarbital sodium obat apa You Should Know
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pentobarbital decreases effects of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. Coadministration of CYP3A4 inducers may perhaps decrease sufentanil levels and efficacy, perhaps precipitating withdrawal syndrome in sufferers which have developed Actual physical dependence to sufentanil. Discontinuation of concomitantly used CYP3A4 inducers may improve sufentanil plasma concentration.
Contraindicated (1)pentobarbital will lower the extent or effect of cariprazine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is liable for the development and elimination of cariprazine's Lively metabolites.
pentobarbital will minimize the level or effect of triazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will reduce the level or effect of ramelteon by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unidentified.
Keep an eye on Intently (one)pentobarbital will decrease the level or effect of mestranol by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will reduce the extent or effect of fentanyl transdermal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead to a minimize in fentanyl plasma concentrations, not enough efficacy or, maybe, development of the withdrawal syndrome in the affected person who has developed Actual physical dependence to fentanyl.
pentobarbital will decrease the extent or effect of conjugated estrogens, vaginal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital decreases levels of elvitegravir/cobicistat/emtricitabine/tenofovir DF by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. May perhaps bring about loss of virologic response and achievable resistance.
pentobarbital will lessen the extent or effect of itraconazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unknown.
pentobarbital will minimize the level or effect of loratadine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will minimize the level or effect of irinotecan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital boosts effects of ifosfamide by influencing hepatic enzyme CYP2B6 metabolism. Use Caution/Watch. Coadministration of ifosfamide with CYP2B6 inducers may perhaps improve metabolism of ifosfamide to its metabolite. Keep click here an eye on for greater effects/toxicities if put together with CYP2B6 inducers.
pentobarbital will lessen the extent or effect of conivaptan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
pentobarbital decreases amounts of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potent CYP3A4 inducers can lower panobinostat amounts by ~70% and lead to cure failure.